The University of Greifswald is a publicresearch university located in Greifswald, Germany, in the state of Mecklenburg-Vorpommern.
Founded in 1456 (teaching existed since 1436), it is one of the oldest universities in Europe, with generations of notable alumni and staff having studied or worked in Greifswald. As the fourth-oldest university in present Germany, it was temporarily also the oldest university of the Kingdoms of Sweden (1648–1815) and Prussia (1815–1945), respectively. Approximately two thirds of the 12,000 students are from outside the state. Due to the small-town atmosphere, the pronounced architectural presence of the alma mater across town, and the young, academic flair in the streets, Greifswald is often described as a "university with a town built around it" rather than a town with a university.

The University of Greifswald was founded on 17 October 1456 with the approval of the Holy Roman Empire and the Pope. This was possible due to the great commitment of Greifswald's lord mayor, Heinrich Rubenow, who was also to become the university's first rector, with the support of Duke Wartislaw IX of Pomerania and Bishop Henning Iven of the local St Nicolas' Cathedral. The founding took place in the local cathedral, which was later remodeled byCaspar David Friedrich and his brother and can still be visited today. The founding of the university was made possible by a decree that restricted teaching activity at the University of Rostock (founded 1419). Several professors left Rostock for Greifswald to continue their work there, where Heinrich Rubenow took the chance of establishing his own university. Originally, the university consisted of the four traditional divisions: Theology, Philosophy, Medicine and Law.
In Germany, there are only three older universities by count of the years of existence: the University of Heidelberg (established 1386), theUniversity of Leipzig (1409), and the University of Rostock (1419).

International co-operation with other institutions of higher
education in northern Europe existed already in the earliest years, sparked and accelerated by the transnational trading network Hanse. From 1456 until 1526, 476 Scandinavians were enrolled at Greifswald University and 22 faculty members as well as six rectors came from Scandinavia. This was a relatively high percentage compared to the total number of students at the time. Sources suggest a relatively segregated life of Swedish students in the primarily German university though. The early sixteenth century saw significant co-operation of the university, the Lutheran church, the city and the Duchy of Pomerania. Professors of theology simultaneously served as pastors in the three cathedrals. Professors of medicine usually served as personal physicians of the duke. Professors of law where also working at the local courts while professors of the faculty of philosophy usually taught the sons and daughters of the ducal family. The landed nobility also funded university-related purposes such as scholarships and student bursaries.
The Reformation was introduced at the university in 1539. Johannes Bugenhagen, an alumnus of the university, was an important figure during the German and Scandinavian reformation as well as a good friend of Martin Luther. After the secularisation of the monastery at Eldena near Greifswald, Duke Philipp I of Pomerania gave all revenue created by the now secularised Amt Eldena to the university. His successor, Duke Ernst Ludwig, began the construction of a college building, which could only be completed after his death. Duke Philipp Juliuspresented the university agown that was used by the rector on ceremonial occasions up until very recently.